Department of Academic-Industrial Partnerships Promotion

About us
Biorepository and Research Laboratory

TOP > About us > Biorepository and Research Laboratory

The Biorepository and Research Laboratory supports clinical research through the processing, storage, and management of clinical specimens. We also design and perform experiments to develop clinical research in infectious diseases.

Collaborating Institutions

Members

Update date: May 16, 2023

Members
Section chief Moto KIMURA
Senior Researcher Junko S. TAKEUCHI
Senior Researcher Kento FUKANO
Technical Researcher Azusa KAMIKAWA
Technical Researcher Yumiko KITO
Technical Assistant Nozomi ARIYOSHI
Technical Assistant Emiko HATANO
Administrative Assistant Ryoko TAMURA

Achievements

Publications (since the start of the laboratory in 2021)

Publications (peer-reviewed journals)

  • [1] Omicron BA.1 neutralizing antibody response following Delta breakthrough infection compared with booster vaccination of BNT162b2.
    Yamamoto, S., K. Matsuda, K. Maeda, Y. Oshiro, N. Inamura, T. Mizoue, M. Konishi, J. S. Takeuchi, K. Horii, M. Ozeki, H. Sugiyama, H. Mitsuya, W. Sugiura and N. Ohmagari (2023).
    BMC Infect Dis 23(1): 282.
    https://doi.org/10.1186/s12879-023-08272-2

  • [2] Immunogenicity and safety of single booster dose of KD-414 inactivated COVID-19 vaccine in adults: An open-label, single-center, non-randomized, controlled study in Japan.
    Terada-Hirashima, J., Y. Takamatsu, Y. Shimizu, Y. Uemura, J. S. Takeuchi, N. Tomita, K. Matsuda, K. Maeda, S. Yamamoto, A. Fukunaga, N. Ohmagari, A. Mikami, K. Sonoda, M. Ujiie, H. Mitsuya and W. Sugiura (2023).
    Hum Vaccin Immunother 19(1): 2193074.
    https://doi.org/10.1080/21645515.2023.2193074.

  • [3] Validation of the severe COVID-19 prognostic value of serum IL-6, IFN-lambda3, CCL17, and calprotectin considering the timing of clinical need for prediction.
    Yamamoto, K., Y. Ohsiro, T. Suzuki, M. Suzuki, S. Miura, M. Nagashima, N. Iwamoto, J. S. Takeuchi, M. Kimura, W. Sugiura, S. Nebuya, M. Kurokawa and N. Ohmagari (2023).
    PLoS One 18(3): e0279897.
    https://doi.org/10.1371/journal.pone.0279897.

  • [4] Comparison of risk factors for SARS-CoV-2 infection among healthcare workers during Omicron and Delta dominance periods in Japan.
    Li, Y., S. Yamamoto, Y. Oshiro, N. Inamura, T. Nemoto, K. Horii, J. S. Takeuchi, T. Mizoue, M. Konishi, M. Ozeki, H. Sugiyama, W. Sugiura and N. Ohmagari (2023).
    J Hosp Infect 134: 97-107.
    https://doi.org/10.1016/j.jhin.2023.01.018.

  • [5] Neutralizing antibodies following three doses of BNT162b2 vaccine, breakthrough infection, and symptoms during the Omicron predominant wave.
    Yamamoto, S., K. Matsuda, K. Maeda, K. Horii, K. Okudera, Y. Oshiro, N. Inamura, J. S. Takeuchi, M. Konishi, M. Ozeki, T. Mizoue, H. Sugiyama, N. Aoyanagi, H. Mitsuya, W. Sugiura, and N. Ohmagari (2023).
    Int J Infect Dis. 2023 Jan 21 : S1201-9712(23)00023-1.
    https://doi.org/10.1016/j.ijid.2023.01.023.

  • [6] SARS-CoV-2 specific T cell and humoral immune responses upon vaccination with BNT162b2: a 9 months longitudinal study.
    Takeuchi, J. S., A. Fukunaga, S. Yamamoto, A. Tanaka, K. Matsuda, M. Kimura, A. Kamikawa, Y. Kito, K. Maeda, G. Ueda, T. Mizoue, M. Ujiie, H. Mitsuya, N. Ohmagari, and W. Sugiura (2022).
    Scientific Reports 12 (1): 15447.
    https://doi.org/10.1038/s41598-022-19581-y

  • [7] Antibody titers and neutralizing activity in cases of COVID-19 after a single dose of vaccination.
    Okumura, N., S. Saito, Y. Takamatsu, J. S. Takeuchi, Y. Asai, M. Sanada, N. Iwamoto, K. Maeda, H. Mitsuya, and N. Ohmagari (2022).
    J Infect Chemother 28 (12): 1704-1706.
    https://doi.org/10.1016/j.jiac.2022.08.026

  • [8] Protocol of an Exploratory Single-Arm Study to Evaluate the Safety and Immunogenicity of KD-414 as a Booster Vaccine for SARS-CoV-2 in Healthy Adults (KAPIVARA).
    Terayama, Y., N. Tomita, J. Terada-Hirashima, Y. Uemura, Y. Shimizu, J. S. Takeuchi, Y. Takamatsu, K. Maeda, A. Mikami, M. Ujiie, and W. Sugiura (2022).
    Life (Basel) 12 (7).
    https://doi.org/10.3390/life12070966

  • [9] Neutralising activity and antibody titre in 10 patients with breakthrough infections of the SARS-CoV-2 Omicron variant in Japan.
    Okumura, N., S. Tsuzuki, S. Saito, S. I. Hattori, J. S. Takeuchi, T. Saito, M. Ujiie, M. Hojo, N. Iwamoto, W. Sugiura, H. Mitsuya, and N. Ohmagari (2022).
    J Infect Chemother 28 (9): 1340-1343.
    https://doi.org/10.1016/j.jiac.2022.04.018

  • [10] An Association Study of HLA with the Kinetics of SARS-CoV-2 Spike Specific IgG Antibody Responses to BNT162b2 mRNA Vaccine.
    Khor, S. S., Y. Omae, J. S. Takeuchi, A. Fukunaga, S. Yamamoto, A. Tanaka, K. Matsuda, M. Kimura, K. Maeda, G. Ueda, T. Mizoue, M. Ujiie, H. Mitsuya, N. Ohmagari, W. Sugiura, and K. Tokunaga (2022).
    Vaccines (Basel) 10 (4).
    https://doi.org/10.3390/vaccines10040563

  • [11] Successful use of casirivimab/imdevimab anti-spike monoclonal antibodies to enhance neutralizing antibodies in a woman on anti-CD20 treatment with refractory COVID-19.
    Miyazato, Y., K. Yamamoto, Y. Nakaya, S. Morioka, J. S. Takeuchi, Y. Takamatsu, K. Maeda, M. Kimura, W. Sugiura, H. Mitsuya, M. Yano, and N. Ohmagari (2022).
    J Infect Chemother 28 (7): 991-994.
    https://doi.org/10.1016/j.jiac.2022.03.002

  • [12] Association between reactogenicity and SARS-CoV-2 antibodies after the second dose of the BNT162b2 COVID-19 vaccine.
    Yamamoto, S., A. Fukunaga, A. Tanaka, J. S. Takeuchi, Y. Inoue, M. Kimura, K. Maeda, G. Ueda, T. Mizoue, M. Ujiie, W. Sugiura, and N. Ohmagari (2022.)
    Vaccine 40 (13): 1924-1927.
    https://doi.org/10.1016/j.vaccine.2022.02.052

  • [13] Coronavirus Disease 2019 (COVID-19) Breakthrough Infection and Post-Vaccination Neutralizing Antibodies Among Healthcare Workers in a Referral Hospital in Tokyo: A Case-Control Matching Study.
    Yamamoto, S., K. Maeda, K. Matsuda, A. Tanaka, K. Horii, K. Okudera, J. S. Takeuchi, T. Mizoue, M. Konishi, M. Ozeki, H. Sugiyama, N. Aoyanagi, H. Mitsuya, W. Sugiura, and N. Ohmagari (2022).
    Clin Infect Dis 75 (1): e683-e691.
    https://doi.org/10.1093/cid/ciab1048

Reviews in Japanese

  • [1] Current status and issues of drug-resistant HIV
    Sugiura, W., J. S. Takeuchi, T.Kikuchi (2023).
    Journal of clinical and experimental medicine (Igaku no ayumi) 284 (9) 657-661, 2023.
    https://cir.nii.ac.jp/crid/1520576900032883328

preprint